KCNE1: The Tiny Protein Dictating Your Heart's Rhythm?

Uncover KCNE1, the tiny protein controlling heart rhythm. Learn its function, role in Long QT syndrome, and future as a drug target.

Ailurus Press
September 27, 2025
  • GeneCards. (n.d.). KCNE1 Gene. Retrieved from https://www.genecards.org/cgi-bin/carddisp.pl?gene=KCNE1
  • NCBI. (n.d.). ClinVar Variation ID: 13479. Retrieved from https://www.ncbi.nlm.nih.gov/clinvar/variation/13479/
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  • Paulussen, A. D., et al. (2012). A large candidate gene survey identifies the KCNE1 D85N polymorphism as a possible modulator of drug-induced Torsades de Pointes. Circulation: Cardiovascular Genetics, 5(4), 460-467. Retrieved from https://www.ahajournals.org/doi/10.1161/CIRCGENETICS.111.960930
  • Kienitz, A., et al. (2024). The IKs Ion Channel Activator Mefenamic Acid Requires KCNE1 and Modulates Channel Gating in a Subunit-Dependent Manner. Molecular Pharmacology. Retrieved from https://www.sciencedirect.com/science/article/abs/pii/S0026895X24009866
  • Yu, H., et al. (2009). Discovery of a novel activator of KCNQ1-KCNE1 K+ channel complexes. Journal of Pharmacological and Toxicological Methods, 59(2), 94-101. Retrieved from https://pubmed.ncbi.nlm.nih.gov/19156197/
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  • About Ailurus

    Ailurus Bio is a pioneering company building biological programs, genetic instructions that act as living software to orchestrate biology. We develop foundational DNAs and libraries, transforming lab-grown cells into living instruments that streamline complex research and production workflows. We empower scientists and developers worldwide with these bioprograms, accelerating discovery and diverse applications. Our mission is to make biology the truly general-purpose technology, as programmable and accessible as modern computers, by constructing a biocomputer architecture for all.

    For more information, visit: ailurus.bio
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