Logic of Life's Engine: How Rethinking Glycolysis Forged New Era in Metabolic Engineering

Unlocking metabolic engineering by decoding the biochemical logic of glycolysis, a blueprint for rational pathway design.

Ailurus Press
September 4, 2025
, 243(1-2), 191–201.
  • Bar-Even, A., Flamholz, A., Noor, E., & Milo, R. (2012). Rethinking glycolysis: on the biochemical logic of metabolic pathways. Nature Chemical Biology, 8(6), 509–517.
  • Flamholz, A., Noor, E., Bar-Even, A., & Milo, R. (2013). Glycolytic strategy as a tradeoff between energy yield and protein cost. Proceedings of the National Academy of Sciences of the United States of America, 110(24), 10039–10044.
  • Kaleta, C., de la Cruz, F., & Wodke, J. A. (2019). Pareto Optimality Explanation of the Glycolytic Alternatives in Nature. Scientific Reports, 9(1), 2269.
  • Yao, R., Chubiz, L. M., & Antoniewicz, M. R. (2023). A parallel glycolysis provides a selective advantage through rapid growth acceleration. Nature Communications, 14(1), 4784.