Pleiotrophin: The Body's Double-Agent in Repair and Disease?

Explore Pleiotrophin (PTN), a key protein in neuroprotection, bone repair, and cancer. Discover its functions and therapeutic potential.

Ailurus Press
October 10, 2025
(3), 695. https://www.mdpi.com/2227-9059/13/3/695
  • Chen, H., et al. (2023). Pleiotrophin drives a prometastatic immune niche in breast cancer. Journal of Experimental Medicine, 220(5), e20220610. https://rupress.org/jem/article-abstract/220/5/e20220610/213899
  • Wang, J., et al. (2024). Pleiotrophin promote glioma proliferation and invasion by regulating epithelial-mesenchymal transition through the NF-κB pathway. European Journal of Medical Research, 29(1), 208. https://eurjmedres.biomedcentral.com/articles/10.1186/s40001-025-02808-9
  • Jain, S., et al. (2017). Therapeutic silence of pleiotrophin by targeted delivery of siRNA in a human prostate cancer model. PLOS ONE, 12(5), e0177964. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177964
  • Akyel, A., et al. (2022). Association of serum pleiotrophin levels with acute coronary syndrome. International Journal of Cardiovascular Academy, 8(3), 67-71. https://ijcva.org/articles/association-of-serum-pleiotrophin-levels-with-acute-coronary-syndrome/ijca.ijca_11_22
  • R&D Systems. (n.d.). Recombinant Human Pleiotrophin/PTN Protein, CF (252-PL). Bio-Techne. Retrieved from https://www.bio-techne.com/p/proteins-enzymes/recombinant-human-pleiotrophin-ptn-protein-cf_252-pl
  • About Ailurus

    Ailurus Bio is a pioneering company building biological programs, genetic instructions that act as living software to orchestrate biology. We develop foundational DNAs and libraries, transforming lab-grown cells into living instruments that streamline complex research and production workflows. We empower scientists and developers worldwide with these bioprograms, accelerating discovery and diverse applications. Our mission is to make biology the truly general-purpose technology, as programmable and accessible as modern computers, by constructing a biocomputer architecture for all.

    For more information, visit: ailurus.bio
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