RBX1: Cellular Janitor or a Cancer Cell's Best Friend?

Explore RBX1, a key E3 ligase in ubiquitination. Uncover its role in protein degradation, cancer, and targeted therapy like PROTACs.

Ailurus Press
October 27, 2025
, 21(3), 181–200. https://www.nature.com/articles/s41573-021-00371-6
  • Ottis, P., et al. (2017). PROTACs: An Emerging Targeting Technique for Protein Degradation in Drug Discovery. BioEssays, 39(12), 1700247. https://onlinelibrary.wiley.com/doi/full/10.1002%2Fbies.201700247
  • CAS. (n.d.). PROTACs revolutionize small molecule drugs. CAS Insights. https://www.cas.org/resources/cas-insights/protac-drug-development
  • Scott, D. C., et al. (2017). Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex. Structure, 25(7), 1152-1160.e3. https://www.cell.com/structure/fulltext/S0969-2126(17)30127-2
  • Eichner, R., et al. (2023). Targeting E3 ubiquitin ligases and their adaptors as a therapeutic strategy. Experimental & Molecular Medicine, 55, 2333–2344. https://www.nature.com/articles/s12276-023-01087-w
  • Chen, Y., et al. (2022). An integrative pan-cancer analysis revealing the difference of RBX1 between tumor and normal tissues. Frontiers in Immunology, 13, 968777. https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2022.968777/full
  • About Ailurus

    Ailurus Bio is a pioneering company building biological programs, genetic instructions that act as living software to orchestrate biology. We develop foundational DNAs and libraries, transforming lab-grown cells into living instruments that streamline complex research and production workflows. We empower scientists and developers worldwide with these bioprograms, accelerating discovery and diverse applications. Our mission is to make biology the truly general-purpose technology, as programmable and accessible as modern computers, by constructing a biocomputer architecture for all.

    For more information, visit: ailurus.bio
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